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BRAIN Cluster of excellence
Bordeaux Region Aquitaine Initiative for Neurosciences 

Transversal pathophysiology and innovative therapeutics for motor, sleep and attention disorders

Key words: motricity, movement, PD, attention, vigilance, chronobiology, virtual reality, electrophysiology, epidemiological cohort, neuropsychology, psychiatry, cognition, sleep, anatomo-pathology, biobank, surrogate marker, animal models, drug discovery, electrical stimulation, gene therapy, phototherapy, behavioral therapy.

Participants :

Coordinators: Erwan Bezard, Pierre Philip.

Participant Teams: Erwan Bezard, Gwendal Le Masson Marc Landry Blaise Yvert Laurent Groc Daniel Choquet Pier-Vincenzo Piazza.

Associated Teams: Jean-François Dartigues (LabEx Santé Publique); Bernard Mazoyer, Klaus Pétry (LabEx BioImaging), Marc Auriacombe (SanPsy), Pierre Burbaud, Abdelhamid Benazzouz, Thomas Boraud, Jerome Baufreton, Serge Ahmed (IMN)

General objective:


The overall aim of this project is to phenotype relevant motor, sleep and attention disorders in a multi-dimensional way (clinical, biological, morphological and pathophysiological) in order to propose innovative therapeutics based on these categorizations. The LABEX BRAIN has expertise and unique translational capabilities in the following disease groups, all characterized by or involving a disorder of motor function: motor disorders (parkinsonian syndromes, amyotrophic lateral sclerosis (ALS), restless leg syndrome,..) and sleep, wake and attentional disorders (lack of sleep, nocturnal breathing disorders, neurological hypersomnia, attention-deficit hyperactivity disorders, chronic fatigue, depression, mood disorders)

Selected project :

2013:

Does the orexin system corntibute to individual differences in sleep deprivation-induced changes in neurobehavioral function?

LabEx support : 45 000€ for 1 year
Pierre PHILIP (Sanpsy) ; Sophie LAYE (NutriNeuro)

Study of miRNA expression pattern as diagnostic and prognostic biomarker in Amyotrophic Lateral Sclerosis

LabEx support : 44 000€ par an pour 2 ans
Alexandre FAVEREAUX (IINS) ; Gwendal LE MASSON (NCM) ; Anne-Cécile WIELANEK-BACHELET (Centre référence SLA)

2012:

Sommeil, Cognition et Alzheimer (SCOAL)

LabEx support : 47 500€
Teams: P. Philip (SanPsy)

Mise en place d'une collection de ressources biologiques

LabEx support : 47 500k€
Teams: Erwan Bezard (IMN), Wassilios Meissner (IMN)



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