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BRAIN Cluster of excellence
Bordeaux Region Aquitaine Initiative for Neurosciences 

Integrative physiology of synapses and neural networks

Keywords: Structural connectivity, neural networks, circuit design and function, cellular and synaptic properties, signal coding and integration, dynamics of short-/long-term network plasticity, network development, electrophysiology, optophysiology, hybrid computer-biological systems, neuromodulatory systems,motor control, behavioral consequences of network function/dysfunction

Participants :

Coordinators: Christophe Mulle, John Simmers

Participating teams: Bruno Bontempi, Daniel Cattaert; Andreas Frick; Laurent Groc; Cyril Herry; Yann Humeau; Marc Landry; Giovanni Marsicano; Gwen Le Masson, Stéphane Oliet; Blaise Yvert.

Associated teams: Jérôme Baufreton, Thomas Boraud (IMN), Didier Morin, Wim Crusio, (INCIA).

General objective:

Our starting hypothesis is that understanding the operational principles of behaviorally relevant networks requires bridging the gap between the level of elemental neuronal properties (synaptic and intrinsic membrane properties) and that of neural network dynamics. The objective of this project is to provide a comprehensive description of selected neural networks, from constituent neurons and their synaptic connections to the integrated systems level, with the goal to relate the dynamics of neural circuitry to complex functions of the brain and spinal cord. By deciphering the fundamental constructs (anatomical connectivity, cellular and synaptic properties) and modes of operation of identified neuronal assemblies, the aim is then to link these parameters to processes of short- and long-term network plasticity, and ultimately to adaptive CNS function under normal physiological and physiopathological conditions, in the adult and during the course of development. In a search for unifying principles, our focus will range from selected simpler networks of invertebrates to the mammalian brainstem and spinal cord regions controlling motor functions and nociception, to hippocampal and cortical circuits involved in cognition.

Projects selected :

2013 :

Unraveling the anatomical wiring diagram to understand the physiology and pathophysiology of the hippocampus and neocortex

LabEx support : 58 000€/year for 2 years

Teams : Christophe MULLE (IINS); Andreas FRICK (NCM)

Programming support for dynamic clamp hybrid systems applications

LabEx support : 34000€ /year for 2 years


2012 :

Unraveling the anatomical wiring diagram to understand the physiology and pathophysiology of the hippocampus and neocortex

LabEx support: 47 000€

Teams: Christophe Mulle (IINS), Andreas Frick (NCM)

Programing support for hybrid systems applications

LabEx support: 48 000€
Teams: John Simmers (INCIA), Gwendal Lemasson (NCM), Daniel Cattaert (INCIA)